Endocrine Abstracts

Obesity is a life-threatening, yet common condition that often lies at the root of other serious illnesses such as diabetes, cardiovascular disease and other neuroendocrine disorders. The central nervous system signalling pathways regulating food intake are complex and the precise mechanisms remain to be determined. Cocaine- and amphetamine- regulated transcript (CART) is a CNS neuropeptide involved in the regulation of feeding.Development of a two-site immunometric assay ...

Background: Self-management is essential for patients with adrenal insufficiency (AI) to achieve optimal outcomes of glucocorticoid (GC) replacement therapy by minimising adverse effects from over- or under-replacement and appropriately adjusting the dose in intercurrent illness to prevent adrenal crisis. Evidence suggests that many patients report deficits in self-management especially concerning ‘sick day rules’, prevention and management of adrenal crisis and have...

Soy phytoestrogens (PE) have been shown to improve insulin resistance and lipids but may adversely affect thyroid function.Objective: To determine the effects of soy PE on thyroid function, insulin resistance and lipid parameters in patients with subclinical hypothyroidism.Design: A randomised, double-blind, crossover study was undertaken involving 60 patients with subclinical hypothyroidism. Patients were randomly assigned to eith...